Author

Akiharu Kubo

Keio UniversityORCID 0000-0003-0902-3586Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Organism:human· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Akari Taniguchi· 1 shared Ayaka Nakai· 1 shared Chiho Shoda· 1 shared Deokho LeeiD· 1 shared Heonuk JeongiD· 1 shared Hiroyuki NakashizukaiD· 1 shared Junichi IkenouchiiD· 1 shared Kazuno NegishiiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperCell Biology

Akari Taniguchi

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2 papers

Recent·Most cited

Cell BiologyeLifePeer-reviewedJul 24, 2025

Rho-ROCK liberates sequestered claudin for rapid de novo tight junction formation

Yuma Cho, Akari Taniguchi, Akiharu Kubo, Junichi Ikenouchi

This study identifies the Rho-ROCK pathway's role in cleaving EpCAM/TROP2 to release claudin for rapid de novo tight junction formation during epithelial turnover.

9 citations

humanproteomics

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Molecular BiologybioRxivPreprintDec 7, 2023

Tight junction component protein claudin-1 deficiency in retinal pigment epithelium leads to early and intermediate age-related macular degeneration phenotypes in mice.

Ayaka Nakai, Deokho Lee, Yan Zhang…·Toshihide Kurihara

This study shows that claudin-1 deficiency in mouse retinal pigment epithelium leads to AMD-like phenotypes including drusenoid deposits and pigment abnormalities.

3 citations

mouseexperimental assay

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