Successful dendritic cell vaccines require lasting in-situ TNF α secretion to license antitumor CD8 + T cell cytotoxicity
Nadine Santana-Magal, Aseel Khateeb, Kfir Inbal, Annette Gleiberman, Ayelet Kaminitz, Tomer Weiss, Gal Verbin, Alon Richter, Amichai Zarfin, Leen Farhat-Younis, Amit Gutwillig, Adi Frish, Eric Shifrut, Inbal Reuveni, Adi Barzel, , Yaron Carmi
The paper identifies that TNFα secretion by tumor-infiltrating myeloid DCs is critical for CD8 T cell cytotoxicity, and shows that DC vaccines lose this function, limiting their efficacy.
bioRxiv · Apr 8, 2026 · PreprintImmunology