Asaf Madi

The paper identifies that TNFα secretion by tumor-infiltrating myeloid DCs is critical for CD8 T cell cytotoxicity, and shows that DC vaccines lose this function, limiting their efficacy.

The paper develops a framework to identify transcription factors mediating signaling convergence from multiple receptors during cell-cell interactions using single-cell RNA-seq data.

This study tracks changes in CD4 T cell receptor repertoires after immunization using short CDR3 sequences, showing distinct repertoires at different time points post-vaccination.