Author

Ayesha Noorani

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genomics· 4

Signature Assays, Organisms & Methods

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Approach:statistical model· 4 Assay:whole-genome sequencing· 4 Organism:human· 3 Research Focus:phylogenetics / evolution· 2 Research Focus:variant calling· 2

Frequent Co-Authors

Rebecca Claire FitzgeraldiD· 4 shared Iñigo MartincorenaiD· 3 shared Michael R. StrattoniD· 3 shared Ahmad Miremadi· 2 shared Alex CaganiD· 2 shared Andrew HindmarshiD· 2 shared Christopher John PetersiD· 2 shared Jamie M. J. WeaveriD· 2 shared

Activity by Year

2018-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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4 shared papersGenomics

Rebecca Claire FitzgeraldORCID

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4 papers

Recent·Most cited

The mutational landscape of human somatic and germline cells

Luiza Moore, Alex Cagan, Tim H. H. Coorens, Matthew D. C. Neville, Rashesh Sanghvi, Mathijs Arnoud Sanders, Thomas R. W. Oliver, Daniel A. Leongamornlert, Peter Ellis, Ayesha Noorani, Thomas J. Mitchell, Timothy M. Butler, Yvette E. Hooks, Anne Yvonne Warren, Mette Jørgensen, , Raheleh Rahbari

This study compares mutational landscapes in somatic and germline cells across 29 anatomical structures, identifying key mutational signatures and their contributions to different cell types.

Yearbook of pediatric endocrinology · Sep 12, 2022Peer-reviewedGenomics

Extensive phylogenies of human development reveal variable embryonic patterns

Tim H. H. Coorens, Luiza Moore, Philip S. Robinson, Rashesh Sanghvi, Joseph Christopher, James Hewinson, Alex Cagan, Thomas R. W. Oliver, Matthew D. C. Neville, Yvette E. Hooks, Ayesha Noorani, Thomas J. Mitchell, Rebecca Claire Fitzgerald, Peter J. Campbell, Iñigo Martincorena, , Michael R. Stratton

The paper reconstructs phylogenies of human development using whole-genome sequencing to show variable embryonic patterns and lineage asymmetries across individuals and tissues.

bioRxiv · Nov 25, 2020 · PreprintGenomics

Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma

Ayesha Noorani, Xiaodun Li, Martin J Goddard, Jason Crawte, Ludmil B. Alexandrov, Maria Secrier, Matthew Eldridge, Lawrence Bower, Jamie M. J. Weaver, Pierre Lao-Sirieix, Iñigo Martincorena, Irene Debiram–Beecham, Nicola Grehan, Shona MacRae, Shalini Malhotra, , Rebecca Claire Fitzgerald

The paper uses whole genome sequencing and phylogenetic analysis to show that metastases in esophageal adenocarcinoma spread rapidly through a clonal diaspora model.

Nature Genetics · Jan 1, 2020Peer-reviewedGenomics

Low-cost and clinically applicable copy number profiling using repeat DNA

Sam Abujudeh, Sebastian S. Zeki, MCV van Lanschot, Mark Pusung, Jamie M. J. Weaver, X Li, A Noorani, AJ Metz, Jan Bornschein, Lawrence Bower, Ahmad Miremadi, Rebecca Claire Fitzgerald, Edward R. Morrissey, Andy G. Lynch, Ayesha Noorani, , Richard Calvin Turkington

The paper introduces conliga, a method for inferring high-resolution SCNA profiles from a low-cost and simple assay, addressing the need for affordable SCNA analysis in clinical settings.

bioRxiv · Aug 19, 2018 · PreprintGenomics