Author

Daniel A. Leongamornlert

Wellcome Sanger InstituteORCID 0000-0002-3486-3168Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:variant calling· 5 Organism:human· 4 Approach:statistical model· 4 Assay:whole-genome sequencing· 4 Research Focus:differential expression· 2 Approach:experimental assay· 1 Organism:mouse· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

Peter J. CampbelliD· 5 shared Alex CaganiD· 4 shared Emily MitchelliD· 3 shared Iñigo MartincorenaiD· 3 shared Daniel James HodsoniD· 2 shared David G. KentiD· 2 shared Elisa LaurentiiD· 2 shared Francesco MauraiD· 2 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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5 shared papersGenomics

Peter J. CampbellORCID

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5 papers

Recent·Most cited

The long-term effects of chemotherapy on normal blood cells

Emily Mitchell, My H. Pham, Anna Clay, Rashesh Sanghvi, Nicholas Williams, Sandra Pietsch, Joanne I. Hsu, Nina Friesgaard Øbro, Hyunchul Jung, Aditi Vedi, Sarah Moody, Jingwei Wang, Daniel A. Leongamornlert, Michael Spencer Chapman, Ellie Dunstone, , Michael R. Stratton

This study examines the long-term effects of chemotherapy on normal blood cells by analyzing mutation burdens and cell population structure in treated individuals.

Nature Genetics · Jul 1, 2025Peer-reviewedCell Biology

Clonal dynamics and somatic evolution of haematopoiesis in mouse

Chiraag Deepak Kapadia, Nicholas Williams, Kevin J. Dawson, Caroline J. Watson, Matthew J. Yousefzadeh, Duy Tri Le, Kudzai Nyamondo, Sreeya Kodavali, Alex Cagan, Sarah M. Waldvogel, Xiaoyan Zhang, Josephine De La Fuente, Daniel A. Leongamornlert, Emily Mitchell, Marcus Alexander Florez, , Jyoti Nangalia

This study examines clonal dynamics and somatic evolution in mouse haematopoiesis, finding that stem cells accrue mutations at a rate similar to human progenitors and exhibit distinct age-related patterns.

Nature · Mar 5, 2025Peer-reviewedGenomics

The mutational landscape of human somatic and germline cells

Luiza Moore, Alex Cagan, Tim H. H. Coorens, Matthew D. C. Neville, Rashesh Sanghvi, Mathijs Arnoud Sanders, Thomas R. W. Oliver, Daniel A. Leongamornlert, Peter Ellis, Ayesha Noorani, Thomas J. Mitchell, Timothy M. Butler, Yvette E. Hooks, Anne Yvonne Warren, Mette Jørgensen, , Raheleh Rahbari

This study compares mutational landscapes in somatic and germline cells across 29 anatomical structures, identifying key mutational signatures and their contributions to different cell types.

Yearbook of pediatric endocrinology · Sep 12, 2022Peer-reviewedGenomics

Genome-wide mutational signatures of immunological diversification in normal lymphocytes

Heather E. Machado, Emily Mitchell, Nina Friesgaard Øbro, Kirsten Kübler, Megan Davies, Francesco Maura, Daniel A. Leongamornlert, Mathijs Arnoud Sanders, Alex Cagan, Craig McDonald, Miriam Belmonte, Mairi S. Shepherd, Robert J. Osborne, Krishnaa T. A. Mahbubani, Iñigo Martincorena, , Peter J. Campbell

The paper analyzes the mutational landscape of normal lymphocytes, revealing off-target effects of programmed genome engineering and the impact of differentiation and microenvironment exposure.

bioRxiv · Apr 29, 2021 · PreprintGenomics

Revealing the impact of recurrent and rare structural variants in multiple myeloma

Even Holth Rustad, Venkata D. Yellapantula, Dominik Głodzik, Kylee H. Maclachlan, Benjamin T. Diamond, Eileen Mary Boyle, Cody Ashby, Patrick Blaney, Gunes Gundem, Malin L. Hultcrantz, Daniel A. Leongamornlert, Nicos Angelopoulos, Daniel Auclair, Yanming Zhang, Ahmet Doǧan, , Francesco Maura

This study identifies 100 SV hotspots and 31 new candidate driver genes in multiple myeloma, revealing that 63% of SVs remain unexplained and are associated with outlier gene expression.

bioRxiv · Dec 18, 2019 · PreprintGenomics