Matthew Eldridge

Absolute copy number fitting from shallow whole genome sequencing data

The paper evaluates tools for estimating absolute copy numbers from shallow whole genome sequencing data and introduces an improved tool called Rascal.

Genomic copy number predicts oesophageal cancer years before transformation

This study shows genomic copy number changes can predict oesophageal cancer up to 10 years before diagnosis, enabling earlier treatment and reduced unnecessary monitoring.

Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma

The paper uses whole genome sequencing and phylogenetic analysis to show that metastases in esophageal adenocarcinoma spread rapidly through a clonal diaspora model.

GCNA interacts with Spartan and Topoisomerase II to regulate genome stability.

The paper shows GCNA interacts with Topoisomerase II to resolve DNA-protein crosslinks, maintaining genome stability in germline and early embryos.

Integrated clonal analysis reveals circulating tumor DNA in urine and plasma of glioma patients

The paper detects circulating tumor DNA in plasma and urine of glioma patients using sequencing guided by tumor mutations.

GenEditID: an open-access platform for the high-throughput identification of CRISPR edited cell clones

GenEditID is a platform for identifying CRISPR-edited cell clones using deep sequencing and proteomic data, enabling scalable and sensitive gene editing analysis.

Low-cost and clinically applicable copy number profiling using repeat DNA

The paper introduces conliga, a method for inferring high-resolution SCNA profiles from a low-cost and simple assay, addressing the need for affordable SCNA analysis in clinical settings.