Ahmad Miremadi

Polyclonal and clonal organoid models of Barrett oesophagus and oesophageal adenocarcinoma reveal heterogeneity in progression and therapy response

The paper generates organoid models of Barrett oesophagus and oesophageal adenocarcinoma to study disease progression and therapy response.

Spatially resolved transcriptomic and proteomic profiling reveals cell interaction programs that predict Barrett's esophagus progression

This study uses spatial transcriptomic and proteomic profiling to identify cell interaction patterns that predict progression of Barrett's esophagus.

Dual-modality imaging of immunofluorescence and imaging mass cytometry for whole slide imaging with accurate single-cell segmentation

The paper introduces a dual-modality imaging method combining high-resolution immunofluorescence and imaging mass cytometry to generate whole-slide IMC images with accurate single-cell segmentation.

Genomic copy number predicts oesophageal cancer years before transformation

This study shows genomic copy number changes can predict oesophageal cancer up to 10 years before diagnosis, enabling earlier treatment and reduced unnecessary monitoring.

Genomic evidence supports a clonal diaspora model for metastases of esophageal adenocarcinoma

The paper uses whole genome sequencing and phylogenetic analysis to show that metastases in esophageal adenocarcinoma spread rapidly through a clonal diaspora model.

Low-cost and clinically applicable copy number profiling using repeat DNA

The paper introduces conliga, a method for inferring high-resolution SCNA profiles from a low-cost and simple assay, addressing the need for affordable SCNA analysis in clinical settings.