PEG-Free Tunable Poly(2-Oxazoline) Lipids Modulate LNP Biodistribution and Expression In Vivo after Intramuscular Administration
Colin M. Basham, Matt Haney, Yuling Zhao, Konstantin A. Lukyanov, Kyoungtea Kim, Ayse Baysal, Hallie Hutsell, Alexander V. Kabanov, Jacob D. Ramsey
This study develops PEG-free poly(2-oxazoline) lipids for LNPs, showing improved transfection, reduced liver accumulation, and enhanced immune tissue targeting in vivo.
bioRxiv · Jun 5, 2025 · PreprintBioengineering