BioengineeringbioRxivPreprint
PEG-Free Tunable Poly(2-Oxazoline) Lipids Modulate LNP Biodistribution and Expression In Vivo after Intramuscular Administration
Colin M. Basham, Matt Haney, Yuling Zhao…·Jacob D. Ramsey
This study develops PEG-free poly(2-oxazoline) lipids for LNPs, showing improved transfection, reduced liver accumulation, and enhanced immune tissue targeting in vivo.