An inappropriate decline in ribosome levels drives a diverse set of neurodevelopmental disorders
Chunyang Ni, Leqian Yu, Barbara Vona, Dayea Park, Yulei Wei, Daniel A. Schmitz, Yudong Wei, Yi Ding, Masahiro Sakurai, Emily B. Ballard, Yan Liu, Ashwani Kumar, Chao Xing, Hyung‐Goo Kim, Cumhur Gökhan Ekmekçi, , Michael Buszczak
The paper identifies how reduced ribosome levels in neural progenitor cells contribute to neurodevelopmental disorders and shows that mTOR activation can alleviate these defects.
bioRxiv · Jan 9, 2024 · PreprintDevelopmental Biology