Yulei Wei

Comparative single-cell transcriptomic roadmap of mammalian fetal ovarian development

This study creates a cross-species single-cell transcriptomic atlas of early ovarian development in cattle, human, and mouse, identifying shared and species-specific cell types and genes.

TASOR expression in naive embryonic stem cells safeguards their developmental potential

This study identifies TASOR's role in maintaining developmental potential during the transition from naive to primed pluripotency by preventing L1 transposable element activation and subsequent cell death.

Generation of High-fidelity Blastocyst-like Structures from Porcine Expanded Pluripotent stem cell via Chemically inducing cell plasticity

This study generates blastocyst-like structures from porcine pluripotent stem cells using chemical induction, achieving up to 80% efficiency and mimicking natural blastocysts in morphology and transcriptome.

An inappropriate decline in ribosome levels drives a diverse set of neurodevelopmental disorders

The paper identifies how reduced ribosome levels in neural progenitor cells contribute to neurodevelopmental disorders and shows that mTOR activation can alleviate these defects.

Dissecting embryonic and extra-embryonic lineage crosstalk with stem cell co-culture

This study establishes co-cultures of embryonic and extraembryonic stem cells to study lineage crosstalk during early mammalian development, revealing growth inhibition of pluripotent cells by extraembryonic endoderm cells.

Large scale production of human blastoids amenable to modeling blastocyst development and maternal-fetal crosstalk

This paper develops an optimized protocol for large-scale production of human blastoids and identifies signaling pathways and endometrial stromal effects in blastocyst development.

Bovine blastocyst like structures derived from stem cell cultures

The paper develops a method to generate bovine blastocyst-like structures (blastoids) from stem cells, which mimic blastocysts in morphology and transcriptomes.