Leqian Yu

The paper identifies a new rostral midline progenitor population in human embryos using spatial transcriptomics and shows their role in mesoendoderm induction.

This study benchmarks and optimizes Perturb-seq in human pluripotent stem cells, identifying shared regulatory networks during cardiomyocyte differentiation.

GeneCompass is a cross-species foundation model pre-trained on single-cell transcriptomes from human and mouse, integrating biological knowledge to improve gene regulatory mechanism understanding and downstream tasks.

The paper identifies how reduced ribosome levels in neural progenitor cells contribute to neurodevelopmental disorders and shows that mTOR activation can alleviate these defects.

This study establishes co-cultures of embryonic and extraembryonic stem cells to study lineage crosstalk during early mammalian development, revealing growth inhibition of pluripotent cells by extraembryonic endoderm cells.

This paper develops an optimized protocol for large-scale production of human blastoids and identifies signaling pathways and endometrial stromal effects in blastocyst development.

The paper develops a method to generate bovine blastocyst-like structures (blastoids) from stem cells, which mimic blastocysts in morphology and transcriptomes.

This study uses a chemical cocktail to derive and culture bovine trophoblast stem cells, which retain developmental potency.

The paper investigates chromatin architecture changes during human cardiomyocyte differentiation and identifies HERV-H retrotransposons as key regulators of TAD boundaries and gene regulation.