Systematic Evaluation Defines the Limits of Ferroptosis in Cancer Therapy
Kenji Mark Fujihara, Azmi Aziz, Behnia Akbari, Maria Gutierrez-Perez, Gregory Francis, Siham Zentout, Kameng Wu, Nicholas James Clemons, Erdem M. Terzi, Michael E. Pacold, Richard Possemato
This study evaluates ferroptosis induction in cancer therapy, finding that GPX4 inhibition fails to impact tumor growth, while cystine deficiency triggers non-ferroptotic cell death.
bioRxiv · Mar 14, 2026 · PreprintCancer Biology