Michael E. Pacold

This study identifies a neural circuit involving PAEsr1 and VMHvlNpy2r cells that supports the regulation of maternal aggression through plasticity and oxytocin signaling.

This study evaluates ferroptosis induction in cancer therapy, finding that GPX4 inhibition fails to impact tumor growth, while cystine deficiency triggers non-ferroptotic cell death.

This study shows that cysteine restriction in mice causes rapid weight loss by depleting glutathione and coenzyme A, activating stress responses, and increasing lipolysis.

This study identifies CNDP1 as a metabolic vulnerability in brain metastasis, showing its inhibition suppresses metastasis and its expression confers metastatic potential.

The paper identifies DELE1's role in promoting translation-associated homeostasis, growth, and survival in mitochondrial myopathy through the mt-ISR pathway.

This paper demonstrates the successful restoration of valine biosynthesis in mammalian cells by integrating synthetic pathways from E. coli, showing that ancient metabolic pathways can be reactivated in metazoans.

This paper presents a method to rapidly isolate synaptic vesicles and profile their metabolites, revealing that only glutamate and GABA are detectable polar metabolites in SVs.