Richard Possemato

This study evaluates ferroptosis induction in cancer therapy, finding that GPX4 inhibition fails to impact tumor growth, while cystine deficiency triggers non-ferroptotic cell death.

This study shows that inhibiting DNA polymerase epsilon in TNBC triggers an NF-κB-driven inflammatory response and tumor clearance in mice.

This study identifies CNDP1 as a metabolic vulnerability in brain metastasis, showing its inhibition suppresses metastasis and its expression confers metastatic potential.

This study shows that acute inhibition of iron-sulfur cluster biosynthesis in mice leads to metabolic inflexibility, reduced adiposity, and glucose dyshomeostasis, with effects mitigated in aged mice.