Editing of highly homologous gamma-globin genes by nickase deficient Base Editor mitigates large intergenic deletions
Anila George, Nithin Sam Ravi, B Vaishnavi, Srujan Kumar Marepally, Saravanabhavan Thangavel, Shaji Ramachandran Velayudhan, Alok Srivastava, Kumarasamypet Murugesan Mohankumar
This study evaluates the safety of using dCas9-ABE8e for editing gamma-globin genes, showing reduced large deletions compared to nCas9-ABE8e while maintaining editing efficiency.
bioRxiv · Dec 4, 2023 · PreprintMolecular Biology