Shaji Ramachandran Velayudhan

Editing of highly homologous gamma-globin genes by nickase deficient Base Editor mitigates large intergenic deletions

This study evaluates the safety of using dCas9-ABE8e for editing gamma-globin genes, showing reduced large deletions compared to nCas9-ABE8e while maintaining editing efficiency.

Precise modelling and correction of a spectrum of β-thalassemic mutations in human erythroid cells by base editors

This study demonstrates the use of base editors to precisely correct various β-thalassemic mutations in human erythroid cells, showing efficient and scarless mutation correction with normal hemoglobin variants.

Identification of novel HPFH-like mutations by CRISPR base editing that elevates the expression of fetal hemoglobin

This study uses CRISPR base editing to identify novel mutations in the HBG promoter that increase fetal hemoglobin expression without harmful effects.

Polymorphic dynamics of ribosomal proteins gene expression during somatic cell reprogramming and their differentiation into specialized cells-types

The paper examines ribosomal protein gene expression dynamics during somatic cell reprogramming and differentiation, identifying distinct expression patterns and their implications for reprogramming outcomes.