Author

B. A. Holt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 3

Signature Assays, Organisms & Methods

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Approach:statistical model· 3 Assay:proteomics· 2 Organism:bacteria (other)· 1 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

G. A. Kwong· 3 shared P. Qiu· 2 shared H. Liakakos· 1 shared H. S. Lim· 1 shared I. Curro· 1 shared M. Su· 1 shared M. Tuttle· 1 shared Q. Zhuang· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

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3 shared papersBioengineering

G. A. Kwong

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Author profile →

3 papers

Recent·Most cited

Embracing enzyme promiscuity with activity-based compressed biosensing

B. A. Holt, H. S. Lim, M. Su, M. Tuttle, H. Liakakos, P. Qiu, G. A. Kwong

This paper introduces SLICE, a method to select promiscuous protease substrates for compressed sensing, enabling accurate classification of complex protease mixtures with fewer substrates.

bioRxiv · Jan 4, 2022Bioengineering

Prodrug defiance reveals logic-based strategies for treating bacterial resistance

B. A. Holt, I. Curro, G. A. Kwong

This paper develops a model to classify bacterial defiance against prodrugs and introduces a dimensionless quantity to predict susceptibility or defiance.

bioRxiv · Sep 23, 2019 · PreprintBioengineering

Deconvolving multiplexed protease signatures with substrate reduction and activity clustering

Q. Zhuang, B. A. Holt, G. A. Kwong, P. Qiu

The paper introduces a computational method to estimate protease activities from multiplexed substrate cleavage data by reducing substrates and clustering proteases into families.

bioRxiv · Mar 1, 2019Bioengineering