P. Qiu

RGS10 deficiency facilitates distant metastasis by inducing epithelial-mesenchymal transition in breast cancer

This study shows RGS10 deficiency promotes breast cancer metastasis via EMT by mechanisms involving lipocalin-2 and miR-539-5p.

Hypoxia impacts small intestinal organoid stemness and differentiation

This study shows that hypoxia increases secretory cells and decreases absorptive cells in mouse small intestinal organoids, impacting stem cell numbers and epithelial regeneration.

Stromal STAT5-mediated trophic activity regulates hematopoietic multipotent progenitor niche factors

This study shows that STAT5ab in stromal cells regulates niche factors critical for hematopoietic progenitor maintenance and function.

Embracing enzyme promiscuity with activity-based compressed biosensing

This paper introduces SLICE, a method to select promiscuous protease substrates for compressed sensing, enabling accurate classification of complex protease mixtures with fewer substrates.

Identifying dysregulated immune cell subsets following critical volumetric muscle loss with pseudo-time trajectories

The paper uses pseudo-time analysis to identify immune cell subset dysregulation in critical versus subcritical volumetric muscle loss in mice.

Activity-based urinary biomarkers of response and resistance to checkpoint blockade immunotherapy

This paper develops INSIGHT, a mass-barcoded peptide sensor for noninvasive monitoring of checkpoint blockade therapy response and resistance in mice.

Deconvolving multiplexed protease signatures with substrate reduction and activity clustering

The paper introduces a computational method to estimate protease activities from multiplexed substrate cleavage data by reducing substrates and clustering proteases into families.

Identification of Variable and Joining germline genes and alleles for Rhesus macaque from B-cell receptor repertoires

This study identifies novel germline V and J alleles in Rhesus macaques by analyzing BCR repertoires and validates them using whole genome sequencing and alignment reference.

Beyond Autoantibodies: Biological Roles Of Human Autoreactive B Cells In Rheumatoid Arthritis Revealed By Whole Transcriptome Profiling

This study identifies novel roles of autoreactive B cells in RA through transcriptome profiling, revealing potential therapeutic targets and mechanisms.