Author

Q. Zhuang

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ATAC-seq· 1 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

A. Hutchins· 1 shared B. A. Holt· 1 shared B. Deng· 1 shared B. Pang· 1 shared B. Sun· 1 shared D. Deng· 1 shared F. Li· 1 shared F. Wang· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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1 shared paperCell Biology

A. Hutchins

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3 papers

Recent·Most cited

Modulating the epigenetic state promotes the reprogramming of transformed cells to pluripotency in a line-specific manner

X. Fu, Q. Zhuang, I. A. Babarinde, L. Shi, G. Ma, H. Hu, Y. Li, J. Chen, Z. Xiao, B. Deng, L. Sun, R. Jauch, A. Hutchins

This study identifies line-specific barriers to reprogramming transformed cells and shows that MEK inhibition can overcome some of these barriers by modulating the epigenetic state.

bioRxiv · Dec 1, 2022 · PreprintCell Biology

Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

Y. Han, Q. Zhuang, B. Sun, W. Lv, S. Wang, Q. Xiao, P. Chi, B. Pang, Y. Zhou, F. Wang, Q. Wang, Z. Li, L. Zhu, F. Li, D. Deng, , R. Ren

The paper reports the crystal structure of PbSRD5A and provides biochemical insights into the conserved mechanism of steroid 5-reductase catalysis.

bioRxiv · Jul 23, 2020Biochemistry

Deconvolving multiplexed protease signatures with substrate reduction and activity clustering

Q. Zhuang, B. A. Holt, G. A. Kwong, P. Qiu

The paper introduces a computational method to estimate protease activities from multiplexed substrate cleavage data by reducing substrates and clustering proteases into families.

bioRxiv · Mar 1, 2019Bioengineering