Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles
S. Kumar, X. Lin, T. Ngo, B. A. Shapero, C. Sou, J. D. Allen, J. Copps, L. Zhang, G. Ozorowski, L. He, M. Crispin, A. B. Ward, I. A. Wilson, J. Zhu
This study isolates HIV-1 neutralizing antibodies from mice and rabbits immunized with gp41-stabilized trimers and nanoparticles, showing they target different epitopes and elicit Env-dependent breadth.
bioRxiv · Dec 2, 2020Microbiology