Author

C. Sou

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Organism:rat· 2 Approach:wet-lab / biochemical assay· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

J. Zhu· 5 shared L. He· 5 shared T. Ngo· 4 shared X. Lin· 4 shared I. A. Wilson· 3 shared A. B. Ward· 2 shared C. Abraham· 2 shared G. Ozorowski· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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5 shared papersMicrobiology

J. Zhu

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Robust and resource-optimal dynamic pattern formation of Min proteins in vivo

z. ren, H. Weyer, L. Wurthner, D. Li, C. Sou, D. Villarreal, E. Frey, S. Jun

This study investigates the robustness and dynamics of Min protein oscillations in E. coli, showing their optimal expression levels and complex patterns under varying conditions.

bioRxiv · Aug 15, 2023 · PreprintBiophysics

Mechanism of a COVID-19 nanoparticle vaccine candidate that elicits a broadly neutralizing antibody response to SARS-CoV-2 variants

Y.-N. Zhang, J. Paynter, C. Sou, T. Fourfouris, Y. Wang, C. Abraham, T. Ngo, Y. Zhang, L. He, J. Zhu

A nanoparticle vaccine candidate induces broadly neutralizing antibodies against multiple SARS-CoV-2 variants through enhanced immune responses.

bioRxiv · Mar 26, 2021Immunology

Neutralizing antibodies induced by first-generation gp41-stabilized HIV-1 envelope trimers and nanoparticles

S. Kumar, X. Lin, T. Ngo, B. A. Shapero, C. Sou, J. D. Allen, J. Copps, L. Zhang, G. Ozorowski, L. He, M. Crispin, A. B. Ward, I. A. Wilson, J. Zhu

This study isolates HIV-1 neutralizing antibodies from mice and rabbits immunized with gp41-stabilized trimers and nanoparticles, showing they target different epitopes and elicit Env-dependent breadth.

bioRxiv · Dec 2, 2020Microbiology

Single-component, self-assembling, protein nanoparticles presenting the receptor binding domain and stabilized spike as SARS-CoV-2 vaccine candidates

L. He, X. Lin, Y. Wang, C. Abraham, C. Sou, T. Ngo, Y. Zhang, I. A. Wilson, J. Zhu

The paper develops SARS-CoV-2 vaccine candidates by displaying the receptor-binding domain and a stabilized spike on self-assembling protein nanoparticles, showing enhanced neutralizing antibody and T-cell responses.

bioRxiv · Sep 14, 2020Microbiology

Single-component multilayered self-assembling nanoparticles presenting rationally designed glycoprotein trimers as Ebola virus vaccines

L. He, A. Chaudhary, X. Lin, C. Sou, T. Alkutkar, S. Kumar, T. Ngo, E. Kosivner, G. Ozorowski, R. Stanfield, A. B. Ward, I. Wilson, J. Zhu

This study designs and tests Ebola virus vaccines using stabilized GP trimers displayed on nanoparticles, showing they induce neutralizing antibodies and enhance infection.

bioRxiv · Aug 22, 2020Microbiology

Rational design of hepatitis C virus E2 core nanoparticle vaccines

L. He, N. Tzarum, X. Lin, B. Shapero, C. Sou, C. Mann, A. Stano, L. Zhang, K. Nagy, E. Giang, M. Law, I. A. Wilson, J. Zhu

This paper presents an HCV vaccine strategy using redesigned E2 cores displayed on nanoparticles to elicit broadly neutralizing B-cell responses.

bioRxiv · Jul 28, 2019Microbiology