Neurovascular mitochondrial susceptibility impacts blood-brain barrier function and behavior
Alexis Mary Crockett, Hania Kébir, M. C. Vélez Colόn, Daniel Maxim Iascone, B. Cielieski, Adam J. Rossano, Amita Sehgal, Stewart A. Anderson, Jorge Ivan Alvarez
This study shows mitochondrial dysfunction in the blood-brain barrier of 22qDS patients and mice, leading to impaired barrier function and social memory, which is corrected by mitochondrial treatment.
bioRxiv · Feb 15, 2024 · PreprintNeuroscience