Author

Jorge Ivan Alvarez

University of PennsylvaniaORCID 0000-0002-8216-5129Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:experimental assay· 2 Organism:mouse· 2 Assay:ATAC-seq· 1 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Hania KébiriD· 3 shared Alexis Mary CrockettiD· 2 shared Stewart A. AndersoniD· 2 shared Adam J. RossanoiD· 1 shared Adriana Hernandez Vásquez· 1 shared Amita SehgaliD· 1 shared Andrew VonHandorfiD· 1 shared Angela Nicole ViaeneiD· 1 shared

Activity by Year

2021-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 23 mutual co-author links

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3 shared papersNeuroscience

Hania KébirORCID

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4 papers

Recent·Most cited

Enhanced EBNA2-dependent activity in EBV-transformed B cells from patients with multiple sclerosis

Marissa Granitto, Ellie Kim, Carmy R. Forney, Cailing Yin, Arame A. Diouf, Andrew VonHandorf, Phillip J. Dexheimer, Sreeja Parameswaran, Xiaoting Chen, Omer A. Donmez, Hope Rowden, Casey O. Swoboda, Molly Shook, Katelyn A. Dunn, Hania Kébir, , Matthew T. Weirauch

This study shows that EBNA2 activity is increased in MS patients, altering gene expression and chromatin accessibility in EBV-transformed B cells.

medRxiv · Mar 9, 2026 · PreprintGenetic & Genomic Medicine

Astroglial Dysfunction, Demyelination and Nodular inflammation in Necrotizing Meningoencephalitis

Sara I Hernandez, Charles‐Antoine Assenmacher, Molly E. Church, Jorge Ivan Alvarez

This study identifies distinct inflammatory patterns in Necrotizing Meningoencephalitis (NME) compared to Granulomatous Meningoencephalomyelitis (GME), highlighting reduced astrogliosis and AQP4 expression as key features.

bioRxiv · Nov 11, 2024 · PreprintNeuroscience

Neurovascular mitochondrial susceptibility impacts blood-brain barrier function and behavior

Alexis Mary Crockett, Hania Kébir, M. C. Vélez Colόn, Daniel Maxim Iascone, B. Cielieski, Adam J. Rossano, Amita Sehgal, Stewart A. Anderson, Jorge Ivan Alvarez

This study shows mitochondrial dysfunction in the blood-brain barrier of 22qDS patients and mice, leading to impaired barrier function and social memory, which is corrected by mitochondrial treatment.

bioRxiv · Feb 15, 2024 · PreprintNeuroscience

Disruption of the blood brain barrier in 22q11.2 deletion syndrome

Alexis Mary Crockett, Sean K. Ryan, Adriana Hernandez Vásquez, Caroline Canning, Nickole Kanyuch, Hania Kébir, Guadalupe Ceja, James Gesualdi, Elaine H. Zackai, Donna M. McDonald‐McGinn, Angela Nicole Viaene, Richa Kapoor, Naïl Benallegue, Raquel E. Gur, Stewart A. Anderson, Jorge Ivan Alvarez

This study shows that the blood brain barrier in 22q11.2 deletion syndrome is compromised, leading to increased neuroinflammation and potential risk for neuropsychiatric disorders.

Brain · Mar 2, 2021Peer-reviewedNeuroscience