Daniel Maxim Iascone

Clustered Inputs Maximize Efficiency for Stable Place Field Encoding in Hippocampal Pyramidal Neurons

The paper shows that clustered excitatory synapses on dendrites improve place field encoding efficiency in hippocampal neurons compared to randomized distributions.

Tanycyte Bmal1 sex-specifically regulates weight gain and hypothalamic neurogenesis in female mice

This study shows that tanycyte Bmal1 deletion in female mice reduces weight gain on high-fat diet by altering hypothalamic neurogenesis, specifically affecting feeding-suppressing POMC neurons.

Neurovascular mitochondrial susceptibility impacts blood-brain barrier function and behavior

This study shows mitochondrial dysfunction in the blood-brain barrier of 22qDS patients and mice, leading to impaired barrier function and social memory, which is corrected by mitochondrial treatment.

BigNeuron: A resource to benchmark and predict best-performing algorithms for automated reconstruction of neuronal morphology

BigNeuron benchmarks automatic neuron reconstruction algorithms using gold standard annotations and image quality metrics, showing that consensus methods outperform individual algorithms.

Whole-neuron synaptic mapping reveals local balance between excitatory and inhibitory synapse organization

The paper maps excitatory and inhibitory synapses across dendritic trees of cortical neurons and finds local balance in their ratio despite domain-specific density variations.

Fast Assembling of Neuron Fragments in Serial 3D Sections

NeuronStitcher is a software suite that stitches non-overlapping neuron fragments from 3D image sections to reconstruct large and complex neurons efficiently.