Robust HIV-1 Replication in the Absence of Integrase Function.
I. D. Irwan, H. L. Karnowski, H. P. Bogerd, K. Tsai, B. Cullen
This study shows HIV-1 can replicate robustly without integrase function in cells expressing HTLV-1 Tax, forming transcriptionally active episomal DNA circles that avoid epigenetic silencing.
bioRxiv · Mar 18, 2020 · PreprintMicrobiology