Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy
K.-S. Park, L. Qin, M. Kabir, K. Luo, B. Dale, Y. Zhong, A. Kim, G. Wang, H. U. Kaniskan, J. Jin
This paper introduces MS147, a novel degrader of PRC1 components BMI1 and RING1B, which selectively degrades these proteins and inhibits cancer cell proliferation.
bioRxiv · Nov 19, 2022Biochemistry