Y. Zhong

Conformational switching of Arp5 subunit differentially regulates INO80 chromatin remodeling

This study identifies two distinct binding mechanisms of the Arp5 subunit in the INO80 chromatin remodeler, showing their differential roles in nucleosome positioning and dimer exchange.

Light-gated Integrator for Highlighting Kinase Activity in Living Cells

This paper introduces KINACT, a light-gated tool that converts kinase activity into permanent fluorescent marks for analyzing kinase dynamics and signaling mechanisms.

Soil viruses reduce greenhouse gas emissions and promote microbial necromass accrual

This study shows soil viruses reduce greenhouse gas emissions and increase microbial necromass, influencing soil carbon storage through viral-mediated microbial mortality.

Protocatechuic acid induces endogenous oxidative stress in CR-hvKP by regulating the EMP-PPP pathway

This study shows that protocatechuic acid (PCA) enhances antibiotic efficacy against carbapenem-resistant hypervirulent Klebsiella pneumoniae by inducing oxidative stress through regulation of the EMP-PPP pathway.

Co-occurrence of ST412 Klebsiella pneumoniae isolates with hypermucoviscous and no-mucoviscous phenotypes in a short-term hospitalized patient

This study identifies co-occurrence of hypermucoviscous and non-hypermucoviscous K. pneumoniae phenotypes in a clonal population, linked to specific mutations and metabolic gene dysregulation.

Enhancing anti-gastrointestinal cancer activities of CLDN18.2 CAR-T armored with novel synthetic NKG2D receptors Containing DAP10 and DAP12 signaling domains.

This paper develops a CAR-T therapy for gastrointestinal cancers by combining CLDN18.2 targeting with synthetic NKG2D receptors containing DAP10 and DAP12 domains, improving efficacy against heterogeneous tumors.

Revisit the Inhibitory Effects of Glucocorticoids on Immunocytes

This study examines the inhibitory effects of dexamethasone on immune cells in Balb/c mice, showing significant reductions in macrophages, DC cells, and monocytes, and suggests GR signaling pathway involvement.

Kindlin-2 inhibits TNF/NF-kB-caspase 8 pathway in hepatocytes to maintain liver development and function

This study shows Kindlin-2 inhibits the TNF/NF-kB-caspase 8 pathway in hepatocytes, preventing liver fibrosis and dysfunction, and identifies it as a potential therapeutic target for liver diseases.

From whole genome to probiotic candidates: a study of potential Lactobacillus strain selection for vaginitis treatment

This study identifies two Lactobacillus strains with probiotic properties for vaginitis treatment using genomic analysis, in vitro tests, and in vivo experiments.

Organization, genomic targeting and assembly of three distinct SWI/SNF chromatin remodeling complexes in Arabidopsis

Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy

This paper introduces MS147, a novel degrader of PRC1 components BMI1 and RING1B, which selectively degrades these proteins and inhibits cancer cell proliferation.

Genetic Dissection of Mutual Interference between Two Consecutively Learned Tasks in Drosophila

This study identifies distinct molecular mechanisms for proactive and retroactive interference in Drosophila during consecutive learning tasks.

Protease inhibitor ASP enhances freezing tolerance by inhibiting protein degradation in Kumquat

A protease inhibitor from kumquat enhances freezing tolerance by stabilizing proteins through inhibition of non-specific protease degradation.

Integrated analysis of intestinal microbiota and metabolomic reveals that decapod iridescent virus 1 (DIV1) infection induces secondary bacterial infection and metabolic reprogramming in Marsupenaeus japonicus

This study investigates how DIV1 infection in Marsupenaeus japonicus affects intestinal microbiota, metabolomics, and immune response, revealing secondary bacterial infection and metabolic reprogramming.

The role of auxiliary domains in modulating CHD4 activity suggests mechanistic commonality between enzyme families

The paper investigates how auxiliary domains in CHD4 modulate its activity, revealing common regulatory mechanisms across chromatin remodelling enzyme families.

Global Spatial Transcriptome of Macaque Brain at Single-Cell Resolution

The paper creates a 3-D cell type atlas of the monkey brain using single-cell spatial transcriptomics and identifies molecular markers for neocortical layers and subregions.

Thyroid hormone induces B cells abnormal differentiation via overexpression of B cell-activating factor

The paper shows that thyroid hormone induces BAFF overexpression, leading to abnormal B cell differentiation in Graves disease.

FoxP3 can fold into two distinct dimerization states with divergent functional implications for T cell homeostasis

This study shows FoxP3 can form two dimerization states, with head-to-head dimerization supporting function and swap-dimerization impairing it.

An oral protein cocktail therapeutic for C. difficile infection

This paper describes an oral protein cocktail, LMN-201, for C. difficile infection, showing it achieves high cure rates and validates spirulina as a delivery platform.

Spatially-resolved transcriptomics analyses of invasive fronts in solid tumors

This study uses spatial transcriptomics to analyze invasive fronts in solid tumors, identifying immune cell enrichment, metabolic changes, and poor prognosis factors.

The complete genome of carbapenem-resistant Escherichia coli ST410 harbored blaNDM-5 isolated from reservoir water in Singapore.

The paper reports the complete genome of a carbapenem-resistant E. coli ST410 strain isolated from Singapore reservoir water, harboring the blaNDM-5 gene.

A genotype independent DMP-HI system in dicot crops

This paper demonstrates a genotype-independent in vivo haploid induction system in dicot crops by mutating DMP genes, achieving HI rates of 1.9%, 2.4%, and 1.2% in tomato, rapeseed, and tobacco respectively.

Reservoir water in Singapore contains ESBL-producing and carbapenem-resistant bacteria with conjugatable conserved gene cluster transfer between different species.

circMRPS35 promotes malignant progression and cisplatin resistance in hepatocellular cancer

This study identifies circMRPS35 as a factor promoting HCC progression and cisplatin resistance through miR-148a-3p sponging and a drug-induced peptide.

A H3K9me2-Binding Protein AGDP3 Limits DNA Methylation and Transcriptional Gene Silencing in Arabidopsis

This study identifies AGDP3 as a protein that binds H3K9me2 and facilitates ROS1-mediated DNA demethylation in Arabidopsis, revealing a mechanism linking histone modification to gene regulation.

High-throughput Single-cell CNV Detection Reveals Clonal Evolution During Hepatocellular Carcinoma Recurrence

This study develops a high-throughput single-cell DNA library preparation method for CNV detection and applies it to identify clonal evolution in hepatocellular carcinoma recurrence.

Selection for Decreased BRCA2 Functional Activity in Homo sapiens After Divergence from the Chimpanzee-Human Last Common Ancestor

The paper identifies a human-specific BRCA2 variant that reduces DNA repair ability, suggesting positive selection for decreased BRCA2 function in human evolution.

Site-specific N-glycosylation Characterization of Recombinant SARS-CoV-2 Spike Proteins

The paper characterizes site-specific N-glycosylation of SARS-CoV-2 spike proteins expressed in human and insect cells, revealing differences in glycan types and their implications for infection and vaccine development.

A Novel Non-hypermucoviscous ST11 Hypervirulent Carbapenem-resistant Klebsiella pneumoniae Lacking Classical Virulence Factors

This study identifies a non-hypermucoviscous ST11 hypervirulent K. pneumoniae strain lacking classical virulence factors, showing increased virulence through ampR and WcaJ mechanisms.

KALRN Mutations Promote Anti-tumor Immunity and Immunotherapy Response in Cancer

This study finds that KALRN mutations enhance anti-tumor immunity and immunotherapy response in cancer by increasing tumor mutation burden and PD-L1 expression.