K.-S. Park

CRACD suppresses neuroendocrinal plasticity of lung adenocarcinoma

This study shows CRACD suppresses neuroendocrinal plasticity in lung adenocarcinoma by restricting cell de-differentiation and stemness-related pathways.

Actin dysregulation induces neuroendocrine plasticity and immune evasion: a vulnerability of small cell lung cancer

This study shows that CRACD, an actin regulator, suppresses neuroendocrine plasticity and immune evasion in SCLC by modulating NOTCH1 and EZH2 pathways, suggesting EZH2 blockade as a potential therapy.

Targeted degradation of PRC1 components, BMI1 and RING1B, via a novel protein complex degrader strategy

This paper introduces MS147, a novel degrader of PRC1 components BMI1 and RING1B, which selectively degrades these proteins and inhibits cancer cell proliferation.

PCLAF-DREAM Drives Alveolar Cell Plasticity for Lung Regeneration

This study identifies PCLAF-DREAM's role in alveolar cell plasticity during lung regeneration and shows a drug candidate can pharmacologically target this process to prevent fibrosis.

A cryptic transactivation domain of EZH2 binds AR and AR's splice variant promoting oncogene activation and tumorous transformation

This study identifies a cryptic transactivation domain of EZH2 that binds AR and AR-V7, promoting oncogene activation and tumorous transformation, and shows that targeting this interaction with a PROTAC reduces tumor growth.

Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD+ regeneration in KRas-mutant lung adenocarcinoma

This study shows that Opa1, not Drp1, is critical for maintaining ETC function and NAD+ regeneration in KRas-mutant lung adenocarcinoma, with Opa1 deletion inhibiting tumor growth.

WNT5A-RHOA axis is a new vulnerability in small-cell lung cancer

This study identifies the WNT5A-RHOA axis as a critical driver of small-cell lung cancer, offering new therapeutic targets and insights into WNT signaling heterogeneity.

Mettl3-mediated m6A modification of Fgf16 restricts cardiomyocyte proliferation during heart regeneration

This study shows that Mettl3-mediated m6A modification of Fgf16 limits cardiomyocyte proliferation and heart regeneration in mice.

Unique role and vulnerability of EP300 KIX domain in small-cell lung cancer

The paper identifies the EP300 KIX domain as a critical driver of SCLC and shows that targeting this domain can inhibit tumor growth.

A First-in-class, Highly Selective and Cell-active AllostericInhibitor of Protein Arginine Methyltransferase 6 (PRMT6)

This paper reports the discovery of a first-in-class, highly selective allosteric inhibitor of PRMT6, SGC6870, with potent activity and selectivity in vitro and in cells.

FGFR1 is critical for Rbl2 loss-driven tumor development and requires PLCG1 activation for continued growth of small cell lung cancer

This study identifies FGFR1's role in SCLC development and growth, showing its dependency on Rbl2 loss and PLCG1 activation.

Fragmentation of Small-cell Lung Cancer Regulatory States in Heterotypic Microenvironments

This study identifies regulatory state heterogeneity in small-cell lung cancer cells in vitro and in vivo, showing increased fragmentation in the liver and its prognostic relevance in human tumors.

A trans-eQTL network regulates osteoclast multinucleation and bone mass

The paper identifies a trans-eQTL network (MMnet) that regulates osteoclast multinucleation and bone mass in mice and humans.