Real Time In vivo Analysis of Pancreatic Beta-cell Autophagic Flux Reveals Impairment Before Onset of Autoimmune Diabetes
O. Melnyk, C. Muralidharan, B. Duffett, A. N. Novak, G. Perez-Aviles, M. M. Martinez, J. J. Crowder, A. K. Linnemann
This study uses intravital microscopy to show autophagic flux defects in NOD mouse beta-cells before hyperglycemia onset, suggesting a causal role in T1D pathogenesis.
bioRxiv · May 23, 2023 · PreprintCell Biology