Discovery of diverse human BH3-only and non-native peptide binders of pro-apoptotic BAK indicate that activators and inhibitors use asimilar binding mode and are not distinguished by binding affinity or kinetics
F. Aguilar, S. Yu, R. A. Grant, S. Swanson, D. Ghose, B. G. Su, K. Sarosiek, A. E. Keating
The paper identifies new BAK binders that show similar binding modes and kinetics to both activators and inhibitors, suggesting sequence-function relationships are not determined by affinity or kinetics.
bioRxiv · May 7, 2022 · PreprintBiochemistry