K. Sarosiek

Pulsed ultrasound promotes secretion of anti-inflammatory extracellular vesicles from skeletal myotubes via elevation of intracellular calcium level

This study shows high-intensity ultrasound increases anti-inflammatory EV secretion from skeletal myotubes by raising intracellular calcium levels, which reduces pro-inflammatory gene expression in macrophages.

In situ architecture of Opa1-dependent mitochondrial cristae remodeling

This study uses cryo-electron tomography to visualize how different Opa1 forms affect mitochondrial cristae architecture and function in mouse cells.

LKB1 regulates JNK-dependent stress signaling and apoptotic dependency of KRAS-mutant lung cancers

This study shows LKB1 suppresses JNK-dependent stress signaling in KRAS-mutant lung cancers, revealing a therapy-induced vulnerability that could improve KRAS-targeted therapies.

Discovery of diverse human BH3-only and non-native peptide binders of pro-apoptotic BAK indicate that activators and inhibitors use asimilar binding mode and are not distinguished by binding affinity or kinetics

The paper identifies new BAK binders that show similar binding modes and kinetics to both activators and inhibitors, suggesting sequence-function relationships are not determined by affinity or kinetics.

A Mesenchymal Tumor Cell State Confers Increased Dependency on the BCL-XL Anti-apoptotic Protein in Kidney Cancer

The paper identifies a mesenchymal tumor cell state that increases dependency on BCL-XL in kidney cancer, showing anti-tumor efficacy of a BCL-XL inhibitor.

Clonal plasma cells in AL amyloidosis are dependent on pro survival BCL-2 family proteins and sensitive to BH3 mimetics

This study identifies that clonal plasma cells in AL amyloidosis depend on BCL-2 family proteins and are sensitive to BH3 mimetics, suggesting potential therapeutic strategies.