Extensive proteomic and transcriptomic changes quench the TCR/CD3 activation signal of latently HIV-1 infected T cells
E. Carlin, B. Greer, A. Duverger, F. Wagner, D. Moylan, A. Dalecki, S. Samuel, M. Perez, K. Lowman, S. Sabbaj, O. Kutsch
This study identifies proteomic and transcriptomic changes in HIV-1 latently infected T cells that render them TCR/CD3 activation-inert, and shows that targeting specific signaling nodes can restore responsiveness and trigger HIV-1 reactivation.
bioRxiv · Jun 29, 2020Microbiology