Author

B. J. Holt

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:differential expression· 1 Research Focus:GWAS / association mapping· 1

Frequent Co-Authors

P. G. Holt· 2 shared A. Bakshi· 1 shared A. Bosco· 1 shared A. C. Jones· 1 shared A. P. Nath· 1 shared A. Salim· 1 shared C. C. Khor· 1 shared D. Anderson· 1 shared

Activity by Year

2019-2019 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersImmunology

P. G. Holt

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2 papers

Recent·Most cited

Rewiring of Th-memory-associated gene co-expression networks underlie immunotherapy-induced changes in symptom expression in mite-sensitised atopics

A. C. Jones, D. Anderson, N. M. Troy, D. Mallon, R. Hartmann, M. Serralha, B. J. Holt, A. Bosco, P. G. Holt

This study shows that immunotherapy induces rewiring of gene co-expression networks in Th-memory responses, leading to stable symptom control through integration of Th2, FOXP3/IL2, inflammation, and Type1-IFN signaling modules.

bioRxiv · Oct 31, 2019 · PreprintImmunology

Neonatal genetics of gene expression reveal the origins of autoimmune and allergic disease risk

Q. Q. Huang, H. H. F. Tang, S. M. Teo, S. C. Ritchie, A. P. Nath, M. Brozynska, A. Salim, A. Bakshi, B. J. Holt, D. Mok, C. C. Khor, P. D. Sly, P. G. Holt, K. E. Holt, M. Inouye

The paper identifies gene expression quantitative trait loci (eQTLs) in neonatal immune cells and links them to autoimmune and allergic disease risk through colocalisation and Mendelian randomisation.

bioRxiv · Jun 27, 2019 · PreprintGenetics