P. G. Holt

Single cell transcriptomics reveals cell type specific features of developmentally regulated responses to lipopolysaccharide between birth and 5 years.

This study uses single cell RNA-sequencing to compare the transcriptional responses to LPS in cord blood and 5-year-old peripheral blood mononuclear cells, revealing developmental changes in immune cell signaling and communication.

Mapping lung hematopoietic progenitors: Developmental kinetics and response to Influenza A viral infection

The paper identifies lung hematopoietic progenitors that change with age and respond to Influenza A infection by altering progenitor populations and immunological homeostasis.

The maternal microbiome regulates infant respiratory disease susceptibility via intestinal Flt3L expression and plasmacytoid dendritic cell hematopoiesis

The paper shows that a maternal low-fibre diet disrupts infant immune development, increasing susceptibility to respiratory infections and asthma, and that propionate-producing bacteria can reverse this effect.

Early-life respiratory viral infection results in impairment of adult lung function

This study establishes a mouse model of early-life respiratory viral infection that leads to adult lung function impairment, showing sex-dependent effects and pathogen-specific outcomes.

Protection against neonatal respiratory viral infection via maternal treatment during pregnancy with the benign immune training agent OM-85

Maternal treatment with OM-85 during pregnancy enhances neonatal resistance to respiratory viral infection by accelerating immune maturation and improving lung immune responses.

Transplacental innate immune training via maternal microbial exposure: a central role for the XBP1-ERN1 axis in programming dendritic cell precursors

This study identifies the XBP1-ERN1 axis as critical for maternal OM-85-induced immune training in fetal dendritic cell precursors, enhancing postnatal resistance to airway inflammation.

Rewiring of Th-memory-associated gene co-expression networks underlie immunotherapy-induced changes in symptom expression in mite-sensitised atopics

This study shows that immunotherapy induces rewiring of gene co-expression networks in Th-memory responses, leading to stable symptom control through integration of Th2, FOXP3/IL2, inflammation, and Type1-IFN signaling modules.

Neonatal genetics of gene expression reveal the origins of autoimmune and allergic disease risk

The paper identifies gene expression quantitative trait loci (eQTLs) in neonatal immune cells and links them to autoimmune and allergic disease risk through colocalisation and Mendelian randomisation.