R. Hartmann

Observation of a single protein by ultrafast X-ray diffraction

The paper demonstrates the first X-ray diffraction pattern from a single protein, Escherichia coli GroEL, showing the feasibility of ultrafast imaging of single proteins.

RNase L activating 2'-5' oligoadenlyates bind ABCF1, -3 and Decr-1

The paper identifies ABCF1, ABCF3, and Decr1 as 2'-5' OA binding proteins, showing evolutionary conservation and species-specific interactions, but finds no strong antiviral functions or translation regulation.

Cryo-EM structure of the human NKCC1 transporter reveals mechanisms of ion coupling and specificity

The paper presents a cryo-EM structure of human NKCC1, revealing ion binding sites and mechanisms of ion coupling and specificity.

Effective interferon (IFN)-lambda treatment regimen to control lethal MERS-CoV infection in mice

This study identifies an effective two-dose IFN-lambda regimen that protects mice from lethal MERS-CoV infection by reducing viral load and inflammation.

Spatial alanine metabolism determines local growth dynamics of Escherichia coli colonies

This study investigates spatial alanine metabolism in E. coli biofilms, revealing distinct metabolic roles in different regions that influence colony growth and morphology.

SARS-CoV-2 Elicits Robust Adaptive Immune Responses Regardless of Disease Severity

This study characterizes adaptive immune responses in SARS-CoV-2 recovered patients, finding robust antibody and T-cell responses across disease severities.

Privatization of biofilm matrix in structurally heterogeneous biofilms

The paper investigates structural heterogeneity in biofilms, showing that matrix gene expression varies and that producer cells maintain partial privatization of the matrix, enhancing biofilm robustness.

Type I and III interferons disrupt lung epithelial repair during recovery from viral infection

This study shows that type I and III interferons impair lung epithelial repair during viral infection recovery, increasing disease severity and bacterial susceptibility.

Disparate temperature-dependent virus - host dynamics for SARS-CoV-2 and SARS-CoV in the human respiratory epithelium

This study compares temperature-dependent replication and immune response dynamics of SARS-CoV-2 and SARS-CoV in human airway epithelial cells, highlighting differences in their antiviral responses and transmission efficiency.

2'3'-cGAMP triggers a STING and NF-κB dependent broad antiviral response in Drosophila

This study shows that 2'3'-cGAMP activates dSTING and NF-κB to trigger a broad antiviral response in Drosophila, independent of autophagy and RNAi pathways.

Rewiring of Th-memory-associated gene co-expression networks underlie immunotherapy-induced changes in symptom expression in mite-sensitised atopics

This study shows that immunotherapy induces rewiring of gene co-expression networks in Th-memory responses, leading to stable symptom control through integration of Th2, FOXP3/IL2, inflammation, and Type1-IFN signaling modules.

Flow-induced symmetry breaking in growing bacterial biofilms

This study investigates how fluid flow affects bacterial biofilm growth by combining live imaging and modeling, revealing three distinct growth phases and symmetry changes.

BiofilmQ, a software tool for quantitative image analysis of microbial biofilm communities

BiofilmQ is a software tool that enables automated, high-throughput quantitative analysis of 3D and 2D microbial biofilm communities through image cytometry.

BacStalk: a comprehensive and interactive image analysis software tool for bacterial cell biology

BacStalk is an image analysis tool for bacterial cell biology that enables detailed analysis of morphologically complex bacteria through interactive visualization and quantitative data extraction.

Division of labor during biofilm matrix production

This study shows that genetic division of labor in Bacillus subtilis enhances biofilm productivity by allowing specialized mutants to exchange matrix components, outperforming phenotypic specialization.

Cell adhesion and fluid flow jointly initiate genotype spatial distribution in biofilms

This study investigates how cell adhesion and fluid flow influence genotype spatial distribution in biofilms using Vibrio cholerae, finding that adhesion can both increase and decrease clonal cluster size depending on environmental conditions.