Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate
E. Prieto-Fernandez, L. Egia-Mendikute, L. Vila-Vecilla, A. Bosch, A. Barreira-Manrique, S. Y. Lee, A. Garcia del Rio, A. Antonana-Vildosola, B. Jimenez-Lasheras, L. Moreno-Cugnon, J. Jimenez-Barbero, E. Berra, J. Ereno-Orbea, A. Palazon
This study shows hypoxia reduces SARS-CoV-2 spike protein attachment to epithelial cells by lowering ACE2, NRP1, and HS levels, suggesting hypoxia may limit infection.
bioRxiv · Jan 9, 2021Cell Biology