S. Y. Lee

Vaginal lactobacilli produce anti-inflammatory beta-carboline compounds.

This study identifies beta-carboline compounds produced by vaginal lactobacilli that reduce inflammation by suppressing immune signaling pathways and demonstrate therapeutic potential in a mouse model.

TSC22D, WNK and NRBP gene families exhibit functional buffering and evolved with Metazoa for macromolecular crowd sensing

This study identifies functional relationships between TSC22D, WNK, and NRBP gene families in macromolecular crowding sensing and cell volume regulation across metazoans.

Acceleration of HDL-mediated cellular cholesterol efflux alleviates periodontitis

This study shows hypercholesterolemia contributes to periodontitis and that fenofibrate reduces disease severity by enhancing HDL-mediated cholesterol efflux.

Genome assembly of the rare and endangered Grantham's camellia, Camellia granthamiana

This paper presents a chromosome-scale genome assembly of the rare Camellia granthamiana using PacBio and Omni-C data, providing a resource for conservation and phylogenetic studies.

Proteasome condensate formation is driven by multivalent interactions with shuttle factors and K48-linked ubiquitin chains

This paper identifies that proteasome condensates in yeast form via multivalent interactions involving K48-linked ubiquitin chains, shuttle factors Rad23 and Dsk2, and proteasome receptors, suggesting functional specificity in condensate formation.

Highly Excretable Gold Supraclusters for Translatable In Vivo Raman Imaging of Tumors

This paper develops excretable gold supraclusters for in vivo Raman imaging of tumors, showing high excretion rates and effective tumor detection in mice.

SIC50: Determination of IC50 by an optimized Sobel operator and a vision transformer

SIC50 uses a vision transformer and Sobel operator to determine IC50 from phase-contrast images, validated with four drugs and 1536-well plates.

SNM1A (DCLRE1A) is required for the efficient repair of complex DNA breaks in human cells

This study shows that SNM1A is essential for repairing complex DNA breaks by removing chemically modified ends, enhancing radiation sensitivity in its absence.

Stress-relief function of migrasomal autophagosomeformed by inhibition of autophagosome/lysosome fusion

This study shows that glioblastoma cells use autophagosomes in migrasomes to relieve stress and prevent cell death by inhibiting autophagosome/lysosome fusion.

Proteome-wide microarray-based screening of PAR-binding proteins

The paper identifies 356 PAR-binding proteins using a human protein microarray, revealing new biological roles of PARylation beyond DNA repair.

Defining the spatial distribution of extracellular adenosine revealed a myeloid-dependent immunosuppressive microenvironment in pancreatic ductal adenocarcinoma

This study shows that extracellular adenosine promotes an immunosuppressive microenvironment in PDAC by enhancing myeloid cell infiltration and resistance to immunotherapy, and that blocking adenosine pathway components improves therapeutic outcomes.

Stable nebulization and muco-trapping properties of Regdanvimab/IN-006 support its development as a potent, dose-saving inhaled therapy for COVID-19

This paper demonstrates that IN-006, a reformulated Regdanvimab, effectively traps SARS-CoV-2 virus-like particles in human airway mucus and achieves higher lung concentrations in rats when nebulized compared to intravenous delivery.

A Calcium/Palmitoylation Switch Interfaces the Signaling Networks of Stress Response and Transition to Flowering

The paper identifies a calcium/palmitoylation switch mechanism that regulates flowering time and stress adaptation in plants by controlling the nuclear localization of SOS3/CBL4.

Dysfunctional TRPM8 signalling in the vascular response to environmental cold in ageing.

This study shows that TRPM8 signaling declines with age, impairing vascular responses to cold in mice.

Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate

This study shows hypoxia reduces SARS-CoV-2 spike protein attachment to epithelial cells by lowering ACE2, NRP1, and HS levels, suggesting hypoxia may limit infection.

Stepwise transmigration cascade of T and B cells through the perivascular channel in lymph node high endothelial venules

This study uses intravital imaging to show T and B cells migrate through HEVs via distinct post-luminal steps involving ECs and FRCs, with T and B cells sharing trans-FRC hot spots but not trans-EC ones.

Transcriptional analysis of immune modulatory genes in melanoma treated with PD-1 blockade

The paper identifies key immune genes and develops a transcriptional deviance score to predict immune checkpoint inhibitor responses in melanoma patients.

Biosynthesis of dihydroquercetin in Escherichia coli from glycerol

This study produces dihydroquercetin in E. coli from glycerol by optimizing a biosynthetic pathway and engineering a plant cytochrome P450, achieving 239.4 mg/L of DHQ.

Characterization and Engineering of Streptomyces griseofuscus DSM 40191 as a Potential Host for Heterologous Expression of Biosynthetic Gene Clusters

This paper characterizes Streptomyces griseofuscus DSM 40191 as a potential heterologous host for biosynthetic gene clusters and demonstrates its ability to produce secondary metabolites.

CRISPR-nRAGE, a Cas9 nickase-reverse transcriptase assisted versatile genetic engineering toolkit for E. coli

CRISPR-nRAGE enables DSB-free, single-nucleotide resolution genome editing in E. coli by combining Cas9 nickase and reverse transcriptase, allowing substitutions, deletions, and insertions.

Distribution of Epsilon-Polylysine Synthetases in Coryneform Bacteria Isolated from Cheese and Human Skin

The paper identifies epsilon-polylysine synthetase genes in coryneform bacteria from cheese and human skin, suggesting natural production of epsilon-polylysine in these environments.

Integrative modelling of the full-length human dehydrodolichyl diphosphate synthase using a hybrid computational and experimental approach

The paper presents a structural model of full-length human DHDDS using computational and experimental methods, revealing a helix-loop-helix motif in the C-terminal domain and a DHDDS-NgBR heterodimer structure.

CD38 is a good predictor of anti-PD-1 immunotherapy responsiveness in hepatocellular carcinoma

The paper shows CD38 expression in immune infiltrates predicts response to anti-PD-1 immunotherapy in HCC patients.

Stalk Lodging: A Portable Device for Phenotyping Stalk Bending Strength of Maize and Sorghum

The paper introduces DARLING, a device for field-based phenotyping of stalk strength in maize and sorghum, which induces natural lodging failure patterns and provides quantitative measurements of flexural stiffness and bending strength.

Optimization of Tenocyte Lineage-related Factors from Tonsil-derived Mesenchymal Stem Cells using Response Surface Methodology

This study uses response surface methodology to optimize TGF-β3 concentrations and culture times for enhancing tenocyte-related gene expression in MSCs.

Holographic deep learning for rapid optical screening of anthrax spores

This paper develops a deep learning method using holographic microscopy to rapidly and accurately classify anthrax spores and other pathogens.