Caught in Motion: Human NTHL1 Undergoes Interdomain Rearrangement Necessary for Catalysis
B. L. Carroll, K. E. Zahn, J. P. Hanley, S. S. Wallace, J. A. Dragon, S. Doublie
This study reports the first X-ray structure of human NTHL1, revealing an open conformation essential for catalysis and showing that interdomain rearrangement is critical for DNA binding.
bioRxiv · Aug 13, 2021Biochemistry