Deep Mutational Engineering of broadly-neutralizing and picomolar affinity nanobodies to accommodate SARS-CoV-1 & 2 antigenic polymorphism
A. Laroche, M. L. Orsini Delgado, P. Cuniasse, S. Dubois, R. Sierocki, F. Gallais, S. Debroas, L. Bellanger, S. Simon, B. Maillere, H. Nozach
This study engineers nanobodies with picomolar affinity and broad neutralizing activity against SARS-CoV-1 and SARS-CoV-2 variants using Deep Mutational Engineering.
bioRxiv · Dec 7, 2021 · PreprintBiochemistry