Author

D. M. Altmann

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

R. J. Boyton· 3 shared E. O. Long· 2 shared M. J. W. Sim· 2 shared S. Rajagopalan· 2 shared A. Chandran· 1 shared A. J. Mentzer· 1 shared A. Khan· 1 shared A. Mayer· 1 shared

Activity by Year

2016-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

R. J. Boyton

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Author profile →

5 papers

Recent·Most cited

Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection.

M. Milighetti, Y. Peng, C. C. S. Tan, M. Mark, G. Nageswaran, S. Byrne, T. Ronel, T. Peacock, A. Mayer, A. Chandran, J. Rosenheim, M. Wheelan, X. Yao, G. Liu, S. L. Felce, , B. Chain

The paper identifies high frequency naive T cell precursors that drive rapid T cell responses during early SARS-COV-2 and LCMV infections.

bioRxiv · Nov 8, 2022Immunology

Comparative multi-OMICS single-cell atlas of five COVID-19 (rAdVV and mRNA) vaccines describe unique and distinct mechanisms of action

Y. Singh, A. Schulze-Selting, G. Gabernet, U. Ray, R. Bajaj, M. Ali, M. Loitz, V. Hammer, E. Buena-Atienza, C. Ruschil, J. Huebner, M. Kowarik, M. salker, N. Casadei, S. Nahnsen, , O. Riess

This study compares the mechanisms of action of five COVID-19 vaccines using multi-omics single-cell data, revealing distinct immune responses and cell-type-specific effects.

bioRxiv · Sep 12, 2022 · PreprintImmunology

HLA class II polymorphism influences the immune response to protective antigen and susceptibility to Bacillus anthracis

D. M. Altmann, S. Ascough, R. Ingram, K. Chu, S. Moore, T. Gallagher, H. Dyson, M. Doganay, G. Metan, Y. Ozkul, L. Baillie, E. D. Williamson, J. Robinson, B. Maillere, R. Boyton

This study identifies HLA class II polymorphism effects on CD4+ T cell responses to PA epitopes and susceptibility to Bacillus anthracis.

bioRxiv · Nov 13, 2019 · PreprintImmunology

HLA-C-restricted presentation of a conserved bacterial epitope to an innate NK cell receptor

M. J. W. Sim, S. Rajagopalan, D. M. Altmann, R. J. Boyton, P. D. Sun, E. O. Long

This study identifies a conserved bacterial epitope recognized by HLA-C*05:01 and the NK cell receptor KIR2DS4, suggesting a novel role for NK cells in detecting bacteria.

bioRxiv · Feb 15, 2019Immunology

Canonical and cross-reactive binding of NK cell inhibitory receptors to HLA-C allotypes is dictated by peptides bound to HLA-C

M. J. W. Sim, S. A. Malaker, A. Khan, J. M. Stowell, J. Shabanowitz, M. E. Peterson, S. Rajagopalan, D. F. Hunt, D. M. Altmann, E. O. Long, R. J. Boyton

This study shows that HLA-C bound peptides influence KIR binding specificity, with KIR2DL1 showing broader peptide tolerance than KIR2DL2/3, and cross-reactive binding being highly peptide selective.

bioRxiv · Dec 27, 2016Immunology