Encapsulation of AAVs into protein vault nanoparticles as a novel solution to gene therapy's neutralizing antibody problem
L. T. Collins, W. Beatty, B. Moyo, M. Alves-Bezerra, A. Hurley, Q. Lou, Z. H. Zhou, W. Lagor, G. Bao, S. Ponnazhagan, R. McNally, L. Rome, D. Curiel
This study encapsulates AAVs into protein vault nanoparticles to bypass neutralizing antibodies, enabling effective gene therapy despite preexisting immunity.
bioRxiv · Nov 29, 2023 · PreprintBioengineering