G. Bao

SKP2-mediated FBXO2 proteasomal degradation drives hepatocellular carcinoma progression via stabilizing Hsp47

The paper shows that loss of FBXO2 promotes hepatocellular carcinoma by stabilizing Hsp47 through SKP2-mediated proteasomal degradation.

Electroadhesive hydrogel interface for prolonged mucosal theranostics

This paper develops e-GLUE, an electroadhesive hydrogel interface that enables prolonged mucosal retention and demonstrates its utility in GI theranostics.

Encapsulation of AAVs into protein vault nanoparticles as a novel solution to gene therapy's neutralizing antibody problem

This study encapsulates AAVs into protein vault nanoparticles to bypass neutralizing antibodies, enabling effective gene therapy despite preexisting immunity.

No trade-off between ovary activation and immune protein expression in female bumble bees (Bombus impatiens)

The paper investigates immune protein expression in female bumble bees, finding no trade-off between ovary activation and immunity in workers, unlike queens.

Bioengineering of a human innervated cardiac muscle model

This paper introduces a human innervated cardiac muscle model that demonstrates functional neuro-cardiac junctions and serves as a surrogate system for studying brain-heart diseases.

Protein nanobarcodes enable single-step multiplexed fluorescence imaging

This paper introduces protein nanobarcodes for single-step multiplexed fluorescence imaging, enabling precise analysis of protein combinations.

High Bandwidth Power Electronics and Magnetic Nanoparticles for Multichannel Magnetogenetic Neurostimulation

The paper presents a power electronic system and magnetic nanoparticles enabling three-channel magnetogenetic neurostimulation with selective heating across different frequency ranges.

Sub-second multi-channel magnetic control of select neural circuits in behaving flies

This study demonstrates sub-second, multichannel neural stimulation in flies using magnetic nanoparticles and temperature-sensitive ion channels, improving the temporal resolution of magnetogenetics.

Fracture Mechanics of Human Blood Clots: Measurements of Toughness and Critical Length scales

This study measures the toughness and critical length scales of human blood clots using a modified lap-shear method, finding toughness independent of geometry and loading conditions.

Targeted replacement of full-length CFTR in human airway stem cells by CRISPR/Cas9 for pan-mutation correction in the endogenous locus

This study corrects multiple CFTR mutations in human airway stem cells using CRISPR/Cas9 and AAV vectors, achieving functional restoration in differentiated epithelial cells.

Development of a Novel Class of Self-Assembling dsRNA Cancer Therapeutics: a Proof of Concept Investigation

This paper introduces a novel class of self-assembling dsRNA therapeutics that target specific oncogenic sequences and induce apoptosis in cancer cells.

Nanomorphological and mechanical reconstruction of mesenchymal stem cells during early apoptosis detected by atomic force microscopy

This study investigates changes in mechanical properties and nanomorphology of BMSCs during early apoptosis using AFM and other techniques, finding that mechanical damage precedes apoptotic signals.

Highly Efficient Repair of the ΔF508 Mutation in Airway Stem Cells of Cystic Fibrosis Patients with Functional Rescue of the Differentiated Epithelia

This paper corrects the ΔF508 mutation in CF patient airway stem cells using CRISPR-Cas9 and AAV6, achieving high correction rates and functional rescue in differentiated epithelia.

Gene Correction for SCID-X1 in Long-Term Hematopoietic Stem Cells

This study corrects SCID-X1 in hematopoietic stem cells using CRISPR/Cas9, achieving high integration frequencies and low off-target effects, supporting clinical development.