B. Orcutt-Jahns

The paper profiles cytokine signaling responses in breast cancer patients and finds coordinated dysregulation across pathways and cell types, suggesting immune cell reprogramming and immunosuppression.

This paper develops a quantitative model to evaluate strategies for enhancing cell-selective ligand binding through affinity, valency, and multi-ligand approaches.

The paper builds a dynamical model of common gamma-chain cytokines to predict ligand responses and shows receptor trafficking and tensor factorization are essential for accurate modeling and engineering cell-specific responses.