A. S. Meyer

Bridging DNA contacts allow Dps from E. coli to condense DNA

This study investigates how DNA topology influences the formation of Dps-DNA complexes, showing that DNA supercoils and bridging contacts facilitate nucleation and stabilization of these structures.

Relationships of crystallinity and reaction rates for enzymatic degradation of poly (ethylene terephthalate), PET

The paper investigates how crystallinity affects enzymatic degradation of PET, finding that high crystallinity limits enzyme activity due to conformational constraints and reduces productive sites on the polymer surface.

Systems profiling reveals recurrently dysregulated cytokine signaling responses in ER+ breast cancer patients' blood

The paper profiles cytokine signaling responses in breast cancer patients and finds coordinated dysregulation across pathways and cell types, suggesting immune cell reprogramming and immunosuppression.

Dissecting signaling regulators driving AXL-mediated bypass resistance and associated phenotypes by phosphosite perturbations

The paper uses phosphosite perturbations to identify signaling pathways driving AXL-mediated erlotinib resistance in lung cancer.

Mixed IgG Fc immune complexes exhibit blended binding profiles and refine FcR affinity estimates

This study examines how mixed Fc domain immune complexes bind Fc receptors, showing blended binding profiles and refined affinity estimates for low-affinity interactions.

Cytokine-expression patterns reveal coordinated immunological programs associated with persistent MRSA bacteremia

This study uses tensor-based integration of host transcriptional and proteomic data to identify immunological patterns associated with persistent MRSA bacteremia outcomes.

A stimulus-contingent positive feedback loop enables IFN-β dose-dependent activation of pro-inflammatory genes

The paper shows high-dose IFN-β activates a pro-inflammatory gene program through a stimulus-contingent positive feedback loop in ISGF3, unlike IFN-λ3.

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection

The paper engineers a cytokine/antibody fusion protein that selectively expands regulatory T cells and protects against autoimmune diseases in mouse models.

A genetic model for in vivo proximity labeling of the mammalian secretome

This paper introduces a genetic mouse model for in vivo proximity labeling of the secretome, revealing organ-specific secretory profiles and serum trafficking.

Structured decomposition improves systems serology prediction and interpretation

This paper introduces TMTF, a tensor factorization method that improves data reduction, prediction, and interpretation in systems serology by capturing structured patterns in HIV humoral immune responses.

A quantitative view of strategies to engineer cell-selective ligand binding

This paper develops a quantitative model to evaluate strategies for enhancing cell-selective ligand binding through affinity, valency, and multi-ligand approaches.

Iron can be microbially extracted from Lunar and Martian regolith simulants and 3D printed into tough structural materials

This paper demonstrates using bacteria to extract iron from lunar and Martian regolith simulants and 3D printing the extracted material into stronger structural components.

Analysis and modeling of cancer drug responses using cell cycle phase-specific rate effects

This study develops a computational model to analyze drug effects on cell cycle phases in breast cancer cells and identifies effective drug combinations.

Modeling Cell-Specific Dynamics and Regulation of the Common Gamma Chain Cytokines

The paper builds a dynamical model of common gamma-chain cytokines to predict ligand responses and shows receptor trafficking and tensor factorization are essential for accurate modeling and engineering cell-specific responses.

Measurement and models accounting for cell death capture hidden variation in compound response

The paper shows that measuring only live cell numbers masks differences in compound effects and introduces an approach to include cell death in pharmacologic response analysis.

Single-Molecule Peptide Fingerprinting

This paper introduces a single-molecule FRET-based technique for protein fingerprinting using ClpXP to sequence peptides with high processivity and low sample requirements.

Dissecting FcγR Regulation Through a Multivalent Binding Model

This paper develops a multivalent binding model to predict FcγR-immune complex interactions and enables rational design of immune complexes for desired effector functions.

A Biomaterial Screening Approach to Reveal Microenvironmental Mechanisms of Drug Resistance

This paper screens drug responses across biomaterial platforms to identify ECM-mediated mechanisms of resistance to RTK-targeted therapies and finds that MEK phosphorylation is a key factor.