Staphylococcus aureus counters organic acid anion-mediated inhibition of peptidoglycan cross-linking through robust alanine racemase activity
S. Panda, Y. P. Jayasinghe, D. D. Shinde, E. Bueno, A. Stastny, B. P. Bertrand, S. S. Chaudhari, T. Kielian, F. Cava, D. R. Ronning, V. C. Thomas
This study shows that Staphylococcus aureus counters acetate-mediated inhibition of peptidoglycan cross-linking by maintaining high intracellular D-Ala levels through alanine racemase and limiting D-Ala flux via D-alanine aminotransferase.
bioRxiv · Jan 15, 2024 · PreprintMicrobiology