V. C. Thomas

The Spx stress regulator confers high-level β-lactam resistance and decreases susceptibility to last-line antibiotics in methicillin resistant Staphylococcus aureus

This study identifies Spx as a stress regulator that enhances β-lactam resistance and reduces susceptibility to last-line antibiotics in MRSA through a redox-independent mechanism.

Staphylococcus aureus counters organic acid anion-mediated inhibition of peptidoglycan cross-linking through robust alanine racemase activity

This study shows that Staphylococcus aureus counters acetate-mediated inhibition of peptidoglycan cross-linking by maintaining high intracellular D-Ala levels through alanine racemase and limiting D-Ala flux via D-alanine aminotransferase.

Host autophagy is exploited by the intracellular parasite Toxoplasma gondii to enhance amino acids levels.

This study shows that Toxoplasma gondii exploits host ER-phagy to increase amino acid levels, which supports its persistence and reduces neurological effects in mice.

Metabolic reprogramming and flux to cell envelope precursors in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics

This study shows that mutating the pentose phosphate pathway gene pgl in MRSA increases resistance to beta-lactam antibiotics through metabolic reprogramming and changes in cell envelope precursors.

PGC-1β and ERRα promote glutamine metabolism and colorectal cancer survival via transcriptional regulation of PCK2

This study identifies PCK2 as a target of PGC-1β and ERRα that promotes glutamine metabolism and colorectal cancer survival through transcriptional regulation.

Identification of the main glutamine and glutamate transporters in Staphylococcus aureus and their impact on c-di-AMP production

This study identifies glutamine and glutamate transporters in S. aureus and shows their impact on c-di-AMP production and growth in rich medium.