Germline determinants of the prostate tumor genome
K. E. Houlahan, J. Yuan, T. Schwarz, J. Livingstone, N. S. Fox, W. Jaratlerdsiri, J. van Riet, K. Taraszka, N. Kurganovs, H. Zhu, J. Sietsma Penington, C.-H. Jung, T. N. Yamaguchi, J. Jiang, L. E. Heisler, , P. C. Boutros
The paper identifies germline-determined quantitative trait loci (dQTLs) that influence somatic mutational features in prostate cancer, revealing their impact on tumor epigenome, transcriptome, and proteome.
bioRxiv · Nov 16, 2022 · PreprintCancer Biology