J.-H. Seo

Increased chromatin accessibility mediated by nuclear factor I drives transition to androgen receptor splice variant dependence in castration-resistant prostate cancer

This study shows that ARv7 drives AR activity in castration-resistant prostate cancer through increased chromatin accessibility mediated by NFI factors.

A compendium of Amplification-Related Gain Of Sensitivity (ARGOS) genes in human cancer

The paper identifies ARGOS genes, which are amplified in cancer, have low expression relative to copy number, and are toxic when overexpressed, and validates several as pan-cancer targets.

Cultivation of SAR202 Bacteria from the Ocean

This study successfully cultivates SAR202 bacteria, revealing their slow growth, light inhibition, and metabolic capabilities involving multiple catabolic pathways.

Reconstructing the pressure field around a swimming fish using a physics-informed neural network

This study uses a physics-informed neural network to reconstruct the pressure field around a swimming fish from PIV data, showing improved accuracy compared to traditional methods.

Germline determinants of the prostate tumor genome

The paper identifies germline-determined quantitative trait loci (dQTLs) that influence somatic mutational features in prostate cancer, revealing their impact on tumor epigenome, transcriptome, and proteome.

CREB5 reprograms nuclear interactions to promote resistance to androgen receptor targeting therapies

This study identifies CREB5 as a key driver of resistance to androgen receptor targeting therapies by reprogramming nuclear interactions and activating TGFβ and Wnt signaling pathways.

Allele-specific epigenetic activity in prostate cancer and normal prostate tissue implicates prostate cancer risk mechanisms

This study identifies allele-specific epigenetic activity in prostate cancer and normal tissue, linking it to GWAS risk loci and highlighting tumor-specific regulatory elements.

Reprogramming of the FOXA1 cistrome in treatment-emergent neuroendocrine prostate cancer

The paper identifies FOXA1 reprogramming in NEPC and shows its role in maintaining NE lineage features through epigenomic profiling.

Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

This study identifies two distinct subtypes of neuroendocrine prostate cancer based on neuronal transcription factors and highlights their epigenetic convergence and therapeutic implications.

Predicting master transcription factors from pan-cancer expression data

This paper introduces CaCTS, an algorithm that identifies candidate master transcription factors (MTFs) across 34 cancer types using RNA-seq data, revealing novel MTFs and functional groupings.

Non-coding Somatic Mutations Converge on the PAX8 Pathway in Epithelial Ovarian Cancer

The paper identifies histotype-specific regulatory elements in ovarian cancer by integrating chromatin landscapes and somatic mutations, highlighting the PAX8 pathway's role in tumor development.

Culturing the ubiquitous freshwater actinobacterial acI lineage by supplying a biochemical ‘helper’ catalase

This study successfully cultures two freshwater acI actinobacterial strains by supplementing growth media with catalase, revealing insights into their metabolic preferences and supporting the Black Queen hypothesis.