K. E. Houlahan

The paper analyzes molecular differences in ductal carcinoma in situ (DCIS) by self-reported race and outcome groups, identifying variations in gene expression, tumor microenvironment, and copy number variations between Black and White women.

This study shows germline variants influence somatic evolution in breast cancer by modulating immunoediting, affecting tumor subtype and metastatic potential.

The paper identifies germline-determined quantitative trait loci (dQTLs) that influence somatic mutational features in prostate cancer, revealing their impact on tumor epigenome, transcriptome, and proteome.

This study models pre-neoplasia in human gastric organoids by inactivating TP53, revealing progression to malignant transcriptional programs and clonal dynamics through experimental evolution.

The paper develops a classifier for DCIS recurrence using genomic data from two cohorts and identifies pathways and stroma-specific signatures associated with progression to invasive cancer.

This study creates an in vivo model of MYC-driven breast cancer by combining PIK3CAH1047R mutation with deregulated MYC, showing a normal-to-tumour switch and dependence on MYC for tumor growth.